About Calcitonin gene-related peptide type 1 receptor
Calcitonin gene-related peptide type 1 receptor (CALCRL) is a protein
from Homo sapiens identified by UniProt accession
Q16602, 461 residues long.
MolForge cross-references it against 0 known binders and
201 disease associations.
Target properties
| Protein name | Calcitonin gene-related peptide type 1 receptor |
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| UniProt accession | Q16602 |
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| Gene | CALCRL |
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| Organism | Homo sapiens |
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| Length | 461 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (4)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (201)
Diseases linked to this target (Open Targets).
- migraine disorder · score 0.61
- BMI-adjusted waist-hip ratio · score 0.53
- waist-hip ratio · score 0.50
- migraine without aura · score 0.46
- migraine with aura · score 0.46
- lymphatic malformation 8 · score 0.46
- white matter hyperintensity measurement · score 0.44
- physical activity measurement · score 0.43
- lymphocyte count · score 0.41
- BMI-adjusted waist circumference · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16602-F1 | alphafold | PREDICTED | 78.68 | — |
Amino-acid sequence (461 residues)
MEKKCTLYFL VLLPFFMILV TAELEESPED SIQLGVTRNK IMTAQYECYQ KIMQDPIQQA EGVYCNRTWD GWLCWNDVAA GTESMQLCPD YFQDFDPSEK VTKICDQDGN WFRHPASNRT WTNYTQCNVN THEKVKTALN LFYLTIIGHG LSIASLLISL GIFFYFKSLS CQRITLHKNL FFSFVCNSVV TIIHLTAVAN NQALVATNPV SCKVSQFIHL YLMGCNYFWM LCEGIYLHTL IVVAVFAEKQ HLMWYYFLGW GFPLIPACIH AIARSLYYND NCWISSDTHL LYIIHGPICA ALLVNLFFLL NIVRVLITKL KVTHQAESNL YMKAVRATLI LVPLLGIEFV LIPWRPEGKI AEEVYDYIMH ILMHFQGLLV STIFCFFNGE VQAILRRNWN QYKIQFGNSF SNSEALRSAS YTVSTISDGP GYSHDCPSEH LNGKSIHDIE NVLLKPENLY N
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