About Bcl-2 homologous antagonist/killer
Bcl-2 homologous antagonist/killer (BAK1) is a protein
from Homo sapiens identified by UniProt accession
Q16611, 211 residues long.
MolForge cross-references it against 0 known binders and
478 disease associations.
Target properties
| Protein name | Bcl-2 homologous antagonist/killer |
|---|
| UniProt accession | Q16611 |
|---|
| Gene | BAK1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 211 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (478)
Diseases linked to this target (Open Targets).
- platelet count · score 0.67
- platelet crit · score 0.66
- type 1 diabetes mellitus · score 0.42
- eosinophil count · score 0.42
- mean platelet volume · score 0.41
- chronic lymphocytic leukemia · score 0.40
- eosinophil percentage of leukocytes · score 0.38
- schizophrenia · score 0.36
- Testicular Germ Cell Tumor · score 0.35
- testicular carcinoma · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16611-F1 | alphafold | PREDICTED | 81.31 | — |
Amino-acid sequence (211 residues)
MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YRHQQEQEAE GVAAPADPEM VTLPLQPSST MGQVGRQLAI IGDDINRRYD SEFQTMLQHL QPTAENAYEY FTKIATSLFE SGINWGRVVA LLGFGYRLAL HVYQHGLTGF LGQVTRFVVD FMLHHCIARW IAQRGGWVAA LNLGNGPILN VLVVLGVVLL GQFVVRRFFK S
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