About Serotonin N-acetyltransferase
Serotonin N-acetyltransferase (AANAT) is a protein
from Homo sapiens identified by UniProt accession
Q16613, 207 residues long.
MolForge cross-references it against 0 known binders and
121 disease associations.
Target properties
| Protein name | Serotonin N-acetyltransferase |
|---|
| UniProt accession | Q16613 |
|---|
| Gene | AANAT |
|---|
| Organism | Homo sapiens |
|---|
| Length | 207 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (121)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.38
- mean corpuscular hemoglobin concentration · score 0.36
- mean corpuscular hemoglobin · score 0.29
- blood protein measurement · score 0.27
- reticulocyte measurement · score 0.22
- cutaneous melanoma · score 0.16
- lymphocyte count · score 0.13
- platelet component distribution width · score 0.13
- mean platelet volume · score 0.13
- lymphocyte percentage of leukocytes · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16613-F1 | alphafold | PREDICTED | 86.35 | — |
Amino-acid sequence (207 residues)
MSTQSTHPLK PEAPRLPPGI PESPSCQRRH TLPASEFRCL TPEDAVSAFE IEREAFISVL GVCPLYLDEI RHFLTLCPEL SLGWFEEGCL VAFIIGSLWD KERLMQESLT LHRSGGHIAH LHVLAVHRAF RQQGRGPILL WRYLHHLGSQ PAVRRAALMC EDALVPFYER FSFHAVGPCA ITVGSLTFME LHCSLRGHPF LRRNSGC
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