Transcription factor NF-E2 45 kDa subunit (NFE2)

About Transcription factor NF-E2 45 kDa subunit

Transcription factor NF-E2 45 kDa subunit (NFE2) is a protein from Homo sapiens identified by UniProt accession Q16621, 373 residues long. MolForge cross-references it against 0 known binders and 253 disease associations.

Target properties

Protein name	Transcription factor NF-E2 45 kDa subunit
UniProt accession	Q16621
Gene	NFE2
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (253)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.37
mean corpuscular volume · score 0.35
eosinophil count · score 0.35
Red cell distribution width · score 0.35
blood protein measurement · score 0.34
monocyte count · score 0.34
mean corpuscular hemoglobin concentration · score 0.34
mean corpuscular hemoglobin · score 0.33
platelet count · score 0.32
erythrocyte count · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16621-F1	alphafold	PREDICTED	66.33	—

Amino-acid sequence (373 residues)

MSPCPPQQSR NRVIQLSTSE LGEMELTWQE IMSITELQGL NAPSEPSFEP QAPAPYLGPP PPTTYCPCSI HPDSGFPLPP PPYELPASTS HVPDPPYSYG NMAIPVSKPL SLSGLLSEPL QDPLALLDIG LPAGPPKPQE DPESDSGLSL NYSDAESLEL EGTEAGRRRS EYVEMYPVEY PYSLMPNSLA HSNYTLPAAE TPLALEPSSG PVRAKPTARG EAGSRDERRA LAMKIPFPTD KIVNLPVDDF NELLARYPLT ESQLALVRDI RRRGKNKVAA QNCRKRKLET IVQLERELER LTNERERLLR ARGEADRTLE VMRQQLTELY RDIFQHLRDE SGNSYSPEEY ALQQAADGTI FLVPRGTKME ATD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards