Occludin (OCLN)

About Occludin

Occludin (OCLN) is a protein from Homo sapiens identified by UniProt accession Q16625, 522 residues long. MolForge cross-references it against 0 known binders and 210 disease associations.

Target properties

Protein name	Occludin
UniProt accession	Q16625
Gene	OCLN
Organism	Homo sapiens
Length	522 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (210)

Diseases linked to this target (Open Targets).

Congenital intrauterine infection-like syndrome · score 0.74
pseudo-TORCH syndrome · score 0.55
neurodegenerative disease · score 0.34
serum gamma-glutamyl transferase measurement · score 0.32
total blood protein measurement · score 0.29
Global developmental delay · score 0.26
Primary microcephaly · score 0.26
Cerebral calcification · score 0.26
glioblastoma multiforme · score 0.23
genetic disorder · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16625-F1	alphafold	PREDICTED	65.57	—

Amino-acid sequence (522 residues)

MSSRPLESPP PYRPDEFKPN HYAPSNDIYG GEMHVRPMLS QPAYSFYPED EILHFYKWTS PPGVIRILSM LIIVMCIAIF ACVASTLAWD RGYGTSLLGG SVGYPYGGSG FGSYGSGYGY GYGYGYGYGG YTDPRAAKGF MLAMAAFCFI AALVIFVTSV IRSEMSRTRR YYLSVIIVSA ILGIMVFIAT IVYIMGVNPT AQSSGSLYGS QIYALCNQFY TPAATGLYVD QYLYHYCVVD PQEAIAIVLG FMIIVAFALI IFFAVKTRRK MDRYDKSNIL WDKEHIYDEQ PPNVEEWVKN VSAGTQDVPS PPSDYVERVD SPMAYSSNGK VNDKRFYPES SYKSTPVPEV VQELPLTSPV DDFRQPRYSS GGNFETPSKR APAKGRAGRS KRTEQDHYET DYTTGGESCD ELEEDWIREY PPITSDQQRQ LYKRNFDTGL QEYKSLQSEL DEINKELSRL DKELDDYREE SEEYMAAADE YNRLKQVKGS ADYKSKKNHC KQLKSKLSHI KKMVGDYDRQ KT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards