About Cleavage and polyadenylation specificity factor subunit 6
Cleavage and polyadenylation specificity factor subunit 6 (CPSF6) is a protein
from Homo sapiens identified by UniProt accession
Q16630, 551 residues long.
MolForge cross-references it against 0 known binders and
155 disease associations.
Target properties
| Protein name | Cleavage and polyadenylation specificity factor subunit 6 |
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| UniProt accession | Q16630 |
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| Gene | CPSF6 |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (155)
Diseases linked to this target (Open Targets).
- cancer · score 0.58
- neurodegenerative disease · score 0.46
- acute lymphoblastic leukemia · score 0.37
- chronic myelogenous leukemia · score 0.37
- leukemia · score 0.37
- myelodysplastic syndrome · score 0.37
- body mass index · score 0.36
- cortical surface area measurement · score 0.30
- cortical thickness · score 0.29
- Agents acting on the renin-angiotensin system use measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16630-F1 | alphafold | PREDICTED | 64.49 | — |
Amino-acid sequence (551 residues)
MADGVDHIDI YADVGEEFNQ EAEYGGHDQI DLYDDVISPS ANNGDAPEDR DYMDTLPPTV GDDVGKGAAP NVVYTYTGKR IALYIGNLTW WTTDEDLTEA VHSLGVNDIL EIKFFENRAN GQSKGFALVG VGSEASSKKL MDLLPKRELH GQNPVVTPCN KQFLSQFEMQ SRKTTQSGQM SGEGKAGPPG GSSRAAFPQG GRGRGRFPGA VPGGDRFPGP AGPGGPPPPF PAGQTPPRPP LGPPGPPGPP GPPPPGQVLP PPLAGPPNRG DRPPPPVLFP GQPFGQPPLG PLPPGPPPPV PGYGPPPGPP PPQQGPPPPP GPFPPRPPGP LGPPLTLAPP PHLPGPPPGA PPPAPHVNPA FFPPPTNSGM PTSDSRGPPP TDPYGRPPPY DRGDYGPPGR EMDTARTPLS EAEFEEIMNR NRAISSSAIS RAVSDASAGD YGSAIETLVT AISLIKQSKV SADDRCKVLI SSLQDCLHGI ESKSYGSGSR RERSRERDHS RSREKSRRHK SRSRDRHDDY YRERSRERER HRDRDRDRDR ERDREREYRH R
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