POU domain class 2-associating factor 1 (POU2AF1)

About POU domain class 2-associating factor 1

POU domain class 2-associating factor 1 (POU2AF1) is a protein from Homo sapiens identified by UniProt accession Q16633, 256 residues long. MolForge cross-references it against 0 known binders and 417 disease associations.

Target properties

Protein name	POU domain class 2-associating factor 1
UniProt accession	Q16633
Gene	POU2AF1
Organism	Homo sapiens
Length	256 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (417)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.46
primary biliary cirrhosis · score 0.38
diffuse large B-cell lymphoma · score 0.37
lung carcinoma · score 0.37
lymphoid neoplasm · score 0.37
neoplasm of mature B-cells · score 0.37
carcinoma of liver and intrahepatic biliary tract · score 0.37
cutaneous melanoma · score 0.37
eosinophil percentage of leukocytes · score 0.33
total blood protein measurement · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16633-F1	alphafold	PREDICTED	56.44	—

Amino-acid sequence (256 residues)

MLWQKPTAPE QAPAPARPYQ GVRVKEPVKE LLRRKRGHAS SGAAPAPTAV VLPHQPLATY TTVGPSCLDM EGSVSAVTEE AALCAGWLSQ PTPATLQPLA PWTPYTEYVP HEAVSCPYSA DMYVQPVCPS YTVVGPSSVL TYASPPLITN VTTRSSATPA VGPPLEGPEH QAPLTYFPWP QPLSTLPTST LQYQPPAPAL PGPQFVQLPI SIPEPVLQDM EDPRRAASSL TIDKLLLEEE DSDAYALNHT LSVEGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards