About Tafazzin
Tafazzin (TAFAZZIN) is a protein
from Homo sapiens identified by UniProt accession
Q16635, 262 residues long.
MolForge cross-references it against 0 known binders and
206 disease associations.
Target properties
| Protein name | Tafazzin |
|---|
| UniProt accession | Q16635 |
|---|
| Gene | TAFAZZIN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 262 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (206)
Diseases linked to this target (Open Targets).
- Barth syndrome · score 0.80
- dilated cardiomyopathy · score 0.50
- Abnormality of the cardiovascular system · score 0.47
- cardiomyopathy · score 0.44
- familial isolated dilated cardiomyopathy · score 0.37
- left ventricular noncompaction · score 0.33
- anemia, nonspherocytic hemolytic, due to G6PD deficiency · score 0.27
- endocardial fibroelastosis · score 0.18
- gastric carcinoma · score 0.15
- dilated cardiomyopathy 1A · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16635-F1 | alphafold | PREDICTED | 94.85 | — |
Amino-acid sequence (262 residues)
MPLHVKWPFP AVPPLTWTLA SSVVMGLVGT YSCFWTKYMN HLTVHNREVL YELIEKRGPA TPLITVSNHQ SCMDDPHLWG ILKLRHIWNL KLMRWTPAAA DICFTKELHS HFFSLGKCVP VCRGDGVYQK GMDFILEKLN HGDWVHIFPE GKVNMSSEFL RFKWGIGRLI AECHLNPIIL PLWHVGMNDV LPNSPPYFPR FGQKITVLIG KPFSALPVLE RLRAENKSAV EMRKALTDFI QEEFQHLKTQ AEQLHNHLQP GR
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