MAP kinase-activated protein kinase 3 (MAPKAPK3)

About MAP kinase-activated protein kinase 3

MAP kinase-activated protein kinase 3 (MAPKAPK3) is a protein from Homo sapiens identified by UniProt accession Q16644, 382 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.

Target properties

Protein name	MAP kinase-activated protein kinase 3
UniProt accession	Q16644
Gene	MAPKAPK3
Organism	Homo sapiens
Length	382 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (75)

Diseases linked to this target (Open Targets).

patterned macular dystrophy 3 · score 0.53
pancreatic adenocarcinoma · score 0.28
thyroid gland adenocarcinoma · score 0.28
breast adenocarcinoma · score 0.27
glioblastoma multiforme · score 0.26
ovarian cancer · score 0.23
endometrial cancer · score 0.23
lung adenocarcinoma · score 0.23
schizophrenia · score 0.20
cutaneous melanoma · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16644-F1	alphafold	PREDICTED	81.93	—

Amino-acid sequence (382 residues)

MDGETAEEQG GPVPPPVAPG GPGLGGAPGG RREPKKYAVT DDYQLSKQVL GLGVNGKVLE CFHRRTGQKC ALKLLYDSPK ARQEVDHHWQ ASGGPHIVCI LDVYENMHHG KRCLLIIMEC MEGGELFSRI QERGDQAFTE REAAEIMRDI GTAIQFLHSH NIAHRDVKPE NLLYTSKEKD AVLKLTDFGF AKETTQNALQ TPCYTPYYVA PEVLGPEKYD KSCDMWSLGV IMYILLCGFP PFYSNTGQAI SPGMKRRIRL GQYGFPNPEW SEVSEDAKQL IRLLLKTDPT ERLTITQFMN HPWINQSMVV PQTPLHTARV LQEDKDHWDE VKEEMTSALA TMRVDYDQVK IKDLKTSNNR LLNKRRKKQA GSSSASQGCN NQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards