About Prostacyclin synthase
Prostacyclin synthase (PTGIS) is a protein
from Homo sapiens identified by UniProt accession
Q16647, 500 residues long.
MolForge cross-references it against 0 known binders and
218 disease associations.
Target properties
| Protein name | Prostacyclin synthase |
|---|
| UniProt accession | Q16647 |
|---|
| Gene | PTGIS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 500 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (218)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.42
- essential hypertension, genetic · score 0.40
- hypertension · score 0.37
- essential hypertension · score 0.36
- ulcerative colitis · score 0.33
- heel bone mineral density · score 0.32
- bipolar disorder · score 0.29
- Rare pervasive developmental disorder · score 0.27
- cutaneous melanoma · score 0.18
- glioblastoma multiforme · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16647-F1 | alphafold | PREDICTED | 94.44 | — |
Amino-acid sequence (500 residues)
MAWAALLGLL AALLLLLLLS RRRTRRPGEP PLDLGSIPWL GYALDFGKDA ASFLTRMKEK HGDIFTILVG GRYVTVLLDP HSYDAVVWEP RTRLDFHAYA IFLMERIFDV QLPHYSPSDE KARMKLTLLH RELQALTEAM YTNLHAVLLG DATEAGSGWH EMGLLDFSYS FLLRAGYLTL YGIEALPRTH ESQAQDRVHS ADVFHTFRQL DRLLPKLARG SLSVGDKDHM CSVKSRLWKL LSPARLARRA HRSKWLESYL LHLEEMGVSE EMQARALVLQ LWATQGNMGP AAFWLLLFLL KNPEALAAVR GELESILWQA EQPVSQTTTL PQKVLDSTPV LDSVLSESLR LTAAPFITRE VVVDLAMPMA DGREFNLRRG DRLLLFPFLS PQRDPEIYTD PEVFKYNRFL NPDGSEKKDF YKDGKRLKNY NMPWGAGHNH CLGRSYAVNS IKQFVFLVLV HLDLELINAD VEIPEFDLSR YGFGLMQPEH DVPVRYRIRP
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