Nuclear factor interleukin-3-regulated protein (NFIL3)

About Nuclear factor interleukin-3-regulated protein

Nuclear factor interleukin-3-regulated protein (NFIL3) is a protein from Homo sapiens identified by UniProt accession Q16649, 462 residues long. MolForge cross-references it against 0 known binders and 323 disease associations.

Target properties

Protein name	Nuclear factor interleukin-3-regulated protein
UniProt accession	Q16649
Gene	NFIL3
Organism	Homo sapiens
Length	462 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (323)

Diseases linked to this target (Open Targets).

body mass index · score 0.48
lean body mass · score 0.46
body weight · score 0.43
fat body mass · score 0.42
body height · score 0.38
bilirubin measurement · score 0.34
neurofibrillary tangles measurement · score 0.31
whole body water mass · score 0.30
visceral adipose tissue measurement · score 0.30
base metabolic rate measurement · score 0.29

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16649-F1	alphafold	PREDICTED	57.24	—

Amino-acid sequence (462 residues)

MQLRKMQTVK KEQASLDASS NVDKMMVLNS ALTEVSEDST TGEELLLSEG SVGKNKSSAC RRKREFIPDE KKDAMYWEKR RKNNEAAKRS REKRRLNDLV LENKLIALGE ENATLKAELL SLKLKFGLIS STAYAQEIQK LSNSTAVYFQ DYQTSKSNVS SFVDEHEPSM VSSSCISVIK HSPQSSLSDV SEVSSVEHTQ ESSVQGSCRS PENKFQIIKQ EPMELESYTR EPRDDRGSYT ASIYQNYMGN SFSGYSHSPP LLQVNRSSSN SPRTSETDDG VVGKSSDGED EQQVPKGPIH SPVELKHVHA TVVKVPEVNS SALPHKLRIK AKAMQIKVEA FDNEFEATQK LSSPIDMTSK RHFELEKHSA PSMVHSSLTP FSVQVTNIQD WSLKSEHWHQ KELSGKTQNS FKTGVVEMKD SGYKVSDPEN LYLKQGIANL SAEVVSLKRL IATQPISASD SG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards