About Prostasin
Prostasin (PRSS8) is a protein
from Homo sapiens identified by UniProt accession
Q16651, 343 residues long.
MolForge cross-references it against 0 known binders and
344 disease associations.
Target properties
| Protein name | Prostasin |
|---|
| UniProt accession | Q16651 |
|---|
| Gene | PRSS8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 343 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (344)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.22
- neurodegenerative disease · score 0.21
- head and neck squamous cell carcinoma · score 0.18
- endometrial cancer · score 0.10
- cancer · score 0.09
- hypotrichosis simplex · score 0.09
- non-small cell lung carcinoma · score 0.08
- neoplasm · score 0.08
- uncombable hair syndrome · score 0.08
- diabetes mellitus · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16651-F1 | alphafold | PREDICTED | 83.74 | — |
Amino-acid sequence (343 residues)
MAQKGVLGPG QLGAVAILLY LGLLRSGTGA EGAEAPCGVA PQARITGGSS AVAGQWPWQV SITYEGVHVC GGSLVSEQWV LSAAHCFPSE HHKEAYEVKL GAHQLDSYSE DAKVSTLKDI IPHPSYLQEG SQGDIALLQL SRPITFSRYI RPICLPAANA SFPNGLHCTV TGWGHVAPSV SLLTPKPLQQ LEVPLISRET CNCLYNIDAK PEEPHFVQED MVCAGYVEGG KDACQGDSGG PLSCPVEGLW YLTGIVSWGD ACGARNRPGV YTLASSYASW IQSKVTELQP RVVPQTQESQ PDSNLCGSHL AFSSAPAQGL LRPILFLPLG LALGLLSPWL SEH
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