About Myelin-oligodendrocyte glycoprotein
Myelin-oligodendrocyte glycoprotein (MOG) is a protein
from Homo sapiens identified by UniProt accession
Q16653, 247 residues long.
MolForge cross-references it against 0 known binders and
468 disease associations.
Target properties
| Protein name | Myelin-oligodendrocyte glycoprotein |
|---|
| UniProt accession | Q16653 |
|---|
| Gene | MOG |
|---|
| Organism | Homo sapiens |
|---|
| Length | 247 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (468)
Diseases linked to this target (Open Targets).
- narcolepsy-cataplexy syndrome · score 0.39
- cognitive function measurement · score 0.15
- schizophrenia · score 0.14
- experimental autoimmune encephalomyelitis · score 0.12
- myeloid sarcoma · score 0.12
- Myelitis · score 0.11
- acute disseminated encephalomyelitis · score 0.11
- neuromyelitis optica · score 0.10
- lung carcinoma · score 0.10
- hemoglobin measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16653-F1 | alphafold | PREDICTED | 84.72 | — |
Amino-acid sequence (247 residues)
MASLSRPSLP SCLCSFLLLL LLQVSSSYAG QFRVIGPRHP IRALVGDEVE LPCRISPGKN ATGMEVGWYR PPFSRVVHLY RNGKDQDGDQ APEYRGRTEL LKDAIGEGKV TLRIRNVRFS DEGGFTCFFR DHSYQEEAAM ELKVEDPFYW VSPGVLVLLA VLPVLLLQIT VGLIFLCLQY RLRGKLRAEI ENLHRTFDPH FLRVPCWKIT LFVIVPVLGP LVALIICYNW LHRRLAGQFL EELRNPF
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