Nuclear respiratory factor 1 (NRF1)

About Nuclear respiratory factor 1

Nuclear respiratory factor 1 (NRF1) is a protein from Homo sapiens identified by UniProt accession Q16656, 503 residues long. MolForge cross-references it against 0 known binders and 96 disease associations.

Target properties

Protein name	Nuclear respiratory factor 1
UniProt accession	Q16656
Gene	NRF1
Organism	Homo sapiens
Length	503 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (96)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
platelet count · score 0.44
neuroinflammatory disorder · score 0.37
platelet component distribution width · score 0.35
Red cell distribution width · score 0.35
mean platelet volume · score 0.35
creatinine measurement · score 0.30
platelet crit · score 0.26
femoral hernia · score 0.24
total blood protein measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16656-F1	alphafold	PREDICTED	57.55	—

Amino-acid sequence (503 residues)

MEEHGVTQTE HMATIEAHAV AQQVQQVHVA TYTEHSMLSA DEDSPSSPED TSYDDSDILN STAADEVTAH LAAAGPVGMA AAAAVATGKK RKRPHVFESN PSIRKRQQTR LLRKLRATLD EYTTRVGQQA IVLCISPSKP NPVFKVFGAA PLENVVRKYK SMILEDLESA LAEHAPAPQE VNSELPPLTI DGIPVSVDKM TQAQLRAFIP EMLKYSTGRG KPGWGKESCK PIWWPEDIPW ANVRSDVRTE EQKQRVSWTQ ALRTIVKNCY KQHGREDLLY AFEDQQTQTQ ATATHSIAHL VPSQTVVQTF SNPDGTVSLI QVGTGATVAT LADASELPTT VTVAQVNYSA VADGEVEQNW ATLQGGEMTI QTTQASEATQ AVASLAEAAV AASQEMQQGA TVTMALNSEA AAHAVATLAE ATLQGGGQIV LSGETAAAVG ALTGVQDANG LVQIPVSMYQ TVVTSLAQGN GPVQVAMAPV TTRISDSAVT MDGQAVEVVT LEQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards