Fascin (FSCN1)

About Fascin

Fascin (FSCN1) is a protein from Homo sapiens identified by UniProt accession Q16658, 493 residues long. MolForge cross-references it against 0 known binders and 327 disease associations.

Target properties

Protein name	Fascin
UniProt accession	Q16658
Gene	FSCN1
Organism	Homo sapiens
Length	493 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (327)

Diseases linked to this target (Open Targets).

leukocyte count · score 0.27
head and neck squamous cell carcinoma · score 0.20
endometrial cancer · score 0.18
breast adenocarcinoma · score 0.18
monocyte count · score 0.18
gastric adenocarcinoma · score 0.15
esophageal cancer · score 0.15
hemoglobin measurement · score 0.12
neoplasm · score 0.12
oral squamous cell carcinoma · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16658-F1	alphafold	PREDICTED	94.19	—

Amino-acid sequence (493 residues)

MTANGTAEAV QIQFGLINCG NKYLTAEAFG FKVNASASSL KKKQIWTLEQ PPDEAGSAAV CLRSHLGRYL AADKDGNVTC EREVPGPDCR FLIVAHDDGR WSLQSEAHRR YFGGTEDRLS CFAQTVSPAE KWSVHIAMHP QVNIYSVTRK RYAHLSARPA DEIAVDRDVP WGVDSLITLA FQDQRYSVQT ADHRFLRHDG RLVARPEPAT GYTLEFRSGK VAFRDCEGRY LAPSGPSGTL KAGKATKVGK DELFALEQSC AQVVLQAANE RNVSTRQGMD LSANQDEETD QETFQLEIDR DTKKCAFRTH TGKYWTLTAT GGVQSTASSK NASCYFDIEW RDRRITLRAS NGKFVTSKKN GQLAASVETA GDSELFLMKL INRPIIVFRG EHGFIGCRKV TGTLDANRSS YDVFQLEFND GAYNIKDSTG KYWTVGSDSA VTSSGDTPVD FFFEFCDYNK VAIKVGGRYL KGDHAGVLKA SAETVDPASL WEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards