Guanylate cyclase activator 2B (GUCA2B)

About Guanylate cyclase activator 2B

Guanylate cyclase activator 2B (GUCA2B) is a protein from Homo sapiens identified by UniProt accession Q16661, 112 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Guanylate cyclase activator 2B
UniProt accession	Q16661
Gene	GUCA2B
Organism	Homo sapiens
Length	112 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

cutaneous melanoma · score 0.18
apolipoprotein A 1 measurement · score 0.11
familial idiopathic steroid-resistant nephrotic syndrome · score 0.07
systolic blood pressure · score 0.07
focal segmental glomerulosclerosis · score 0.07
nephrotic syndrome · score 0.06
IGA glomerulonephritis · score 0.06
nail-patella-like renal disease · score 0.06
Liddle syndrome · score 0.06
colorectal cancer · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16661-F1	alphafold	PREDICTED	82.88	—

Amino-acid sequence (112 residues)

MGCRAASGLL PGVAVVLLLL LQSTQSVYIQ YQGFRVQLES MKKLSDLEAQ WAPSPRLQAQ SLLPAVCHHP ALPQDLQPVC ASQEASSIFK TLRTIANDDC ELCVNVACTG CL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards