About Anti-Muellerian hormone type-2 receptor
Anti-Muellerian hormone type-2 receptor (AMHR2) is a protein
from Homo sapiens identified by UniProt accession
Q16671, 573 residues long.
MolForge cross-references it against 0 known binders and
206 disease associations.
Target properties
| Protein name | Anti-Muellerian hormone type-2 receptor |
|---|
| UniProt accession | Q16671 |
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| Gene | AMHR2 |
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| Organism | Homo sapiens |
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| Length | 573 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (206)
Diseases linked to this target (Open Targets).
- persistent Mullerian duct syndrome · score 0.75
- Persistent Müllerian duct syndrome · score 0.74
- genetic non-acquired premature ovarian failure · score 0.44
- neurodegenerative disease · score 0.35
- Male pseudohermaphroditism · score 0.33
- vitamin D measurement · score 0.19
- genetic disorder · score 0.19
- reticulocyte count · score 0.17
- hemoglobin measurement · score 0.16
- body height · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16671-F1 | alphafold | PREDICTED | 77.58 | — |
Amino-acid sequence (573 residues)
MLGSLGLWAL LPTAVEAPPN RRTCVFFEAP GVRGSTKTLG ELLDTGTELP RAIRCLYSRC CFGIWNLTQD RAQVEMQGCR DSDEPGCESL HCDPSPRAHP SPGSTLFTCS CGTDFCNANY SHLPPPGSPG TPGSQGPQAA PGESIWMALV LLGLFLLLLL LLGSIILALL QRKNYRVRGE PVPEPRPDSG RDWSVELQEL PELCFSQVIR EGGHAVVWAG QLQGKLVAIK AFPPRSVAQF QAERALYELP GLQHDHIVRF ITASRGGPGR LLSGPLLVLE LHPKGSLCHY LTQYTSDWGS SLRMALSLAQ GLAFLHEERW QNGQYKPGIA HRDLSSQNVL IREDGSCAIG DLGLALVLPG LTQPPAWTPT QPQGPAAIME AGTQRYMAPE LLDKTLDLQD WGMALRRADI YSLALLLWEI LSRCPDLRPD SSPPPFQLAY EAELGNTPTS DELWALAVQE RRRPYIPSTW RCFATDPDGL RELLEDCWDA DPEARLTAEC VQQRLAALAH PQESHPFPES CPRGCPPLCP EDCTSIPAPT ILPCRPQRSA CHFSVQQGPC SRNPQPACTL SPV
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