Forkhead box protein D1 (FOXD1)

About Forkhead box protein D1

Forkhead box protein D1 (FOXD1) is a protein from Homo sapiens identified by UniProt accession Q16676, 465 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.

Target properties

Protein name	Forkhead box protein D1
UniProt accession	Q16676
Gene	FOXD1
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (161)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
heel bone mineral density · score 0.38
body height · score 0.35
pulse pressure measurement · score 0.34
bone quantitative ultrasound measurement · score 0.29
neurofibrillary tangles measurement · score 0.24
macula measurement · score 0.22
cardiovascular disease · score 0.21
delivery measurement · score 0.19
hereditary breast ovarian cancer syndrome · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16676-F1	alphafold	PREDICTED	56.74	—

Amino-acid sequence (465 residues)

MTLSTEMSDA SGLAEETDID VVGEGEDEED EEEEDDDEGG GGGPRLAVPA QRRRRRRSYA GEDELEDLEE EEDDDDILLA PPAGGSPAPP GPAPAAGAGA GGGGGGGGAG GGGSAGSGAK NPLVKPPYSY IALITMAILQ SPKKRLTLSE ICEFISGRFP YYREKFPAWQ NSIRHNLSLN DCFVKIPREP GNPGKGNYWT LDPESADMFD NGSFLRRRKR FKRQPLLPPN AAAAESLLLR GAGAAGGAGD PAAAAALFPP APPPPPHAYG YGPYGCGYGL QLPPYAPPSA LFAAAAAAAA AAAFHPHSPP PPPPPHGAAA ELARTAFGYR PHPLGAALPG PLPASAAKAG GPGASALARS PFSIESIIGG SLGPAAAAAA AAQAAAAAQA SPSPSPVAAP PAPGSSGGGC AAQAAVGPAA ALTRSLVAAA AAAASSVSSS AALGTLHQGT ALSSVENFTA RISNC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards