About Histone H3.1t
Histone H3.1t (H3-4) is a protein
from Homo sapiens identified by UniProt accession
Q16695, 136 residues long.
MolForge cross-references it against 0 known binders and
134 disease associations.
Target properties
| Protein name | Histone H3.1t |
|---|
| UniProt accession | Q16695 |
|---|
| Gene | H3-4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 136 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (134)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- progressive supranuclear palsy · score 0.08
- partial chromosome Y deletion · score 0.08
- burn · score 0.07
- congenital bilateral absence of vas deferens · score 0.07
- spermatogenic failures 50 · score 0.06
- spermatogenic failure 25 · score 0.06
- isochromosomy Yp · score 0.06
- spinocerebellar ataxia type 32 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16695-F1 | alphafold | PREDICTED | 86.10 | — |
Amino-acid sequence (136 residues)
MARTKQTARK STGGKAPRKQ LATKVARKSA PATGGVKKPH RYRPGTVALR EIRRYQKSTE LLIRKLPFQR LMREIAQDFK TDLRFQSSAV MALQEACESY LVGLFEDTNL CVIHAKRVTI MPKDIQLARR IRGERA
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