About 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial (DECR1) is a protein
from Homo sapiens identified by UniProt accession
Q16698, 335 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial |
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| UniProt accession | Q16698 |
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| Gene | DECR1 |
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| Organism | Homo sapiens |
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| Length | 335 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (152)
Diseases linked to this target (Open Targets).
- progressive encephalopathy with leukodystrophy due to DECR deficiency · score 0.41
- protein measurement · score 0.32
- neurodegenerative disease · score 0.20
- smoking status measurement · score 0.10
- neoplasm · score 0.07
- antisocial behaviour measurement · score 0.06
- substance abuse · score 0.06
- attention deficit hyperactivity disorder · score 0.06
- Young adult-onset Parkinsonism · score 0.05
- Hereditary late-onset Parkinson disease · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16698-F1 | alphafold | PREDICTED | 89.68 | — |
Amino-acid sequence (335 residues)
MKLPARVFFT LGSRLPCGLA PRRFFSYGTK ILYQNTEALQ SKFFSPLQKA MLPPNSFQGK VAFITGGGTG LGKGMTTLLS SLGAQCVIAS RKMDVLKATA EQISSQTGNK VHAIQCDVRD PDMVQNTVSE LIKVAGHPNI VINNAAGNFI SPTERLSPNA WKTITDIVLN GTAFVTLEIG KQLIKAQKGA AFLSITTIYA ETGSGFVVPS ASAKAGVEAM SKSLAAEWGK YGMRFNVIQP GPIKTKGAFS RLDPTGTFEK EMIGRIPCGR LGTVEELANL AAFLCSDYAS WINGAVIKFD GGEEVLISGE FNDLRKVTKE QWDTIEELIR KTKGS
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