NADH dehydrogenase [ubiquinone] 1 alpha subcomplex…

About NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (NDUFA5) is a protein from Homo sapiens identified by UniProt accession Q16718, 116 residues long. MolForge cross-references it against 0 known binders and 237 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5
UniProt accession	Q16718
Gene	NDUFA5
Organism	Homo sapiens
Length	116 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (237)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.55
insulin resistance · score 0.55
neurodegenerative disease · score 0.55

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16718-F1	alphafold	PREDICTED	88.55	—

Amino-acid sequence (116 residues)

MAGVLKKTTG LVGLAVCNTP HERLRILYTK ILDVLEEIPK NAAYRKYTEQ ITNEKLAMVK AEPDVKKLED QLQGGQLEEV ILQAEHELNL ARKMREWKLW EPLVEEPPAD QWKWPI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 (NDUFA5)