Kynureninase (KYNU)

About Kynureninase

Kynureninase (KYNU) is a protein from Homo sapiens identified by UniProt accession Q16719, 465 residues long. MolForge cross-references it against 0 known binders and 262 disease associations.

Target properties

Protein name	Kynureninase
UniProt accession	Q16719
Gene	KYNU
Organism	Homo sapiens
Length	465 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (262)

Diseases linked to this target (Open Targets).

vertebral, cardiac, renal, and limb defects syndrome 2 · score 0.73
congenital vertebral-cardiac-renal anomalies syndrome · score 0.61
encephalopathy due to hydroxykynureninuria · score 0.53
Catel-Manzke syndrome · score 0.48
cataract · score 0.41
blood protein measurement · score 0.41
neurodegenerative disease · score 0.37
lymphocyte count · score 0.37
platelet count · score 0.35
total blood protein measurement · score 0.31

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16719-F1	alphafold	PREDICTED	95.43	—

Amino-acid sequence (465 residues)

MEPSSLELPA DTVQRIAAEL KCHPTDERVA LHLDEEDKLR HFRECFYIPK IQDLPPVDLS LVNKDENAIY FLGNSLGLQP KMVKTYLEEE LDKWAKIAAY GHEVGKRPWI TGDESIVGLM KDIVGANEKE IALMNALTVN LHLLMLSFFK PTPKRYKILL EAKAFPSDHY AIESQLQLHG LNIEESMRMI KPREGEETLR IEDILEVIEK EGDSIAVILF SGVHFYTGQH FNIPAITKAG QAKGCYVGFD LAHAVGNVEL YLHDWGVDFA CWCSYKYLNA GAGGIAGAFI HEKHAHTIKP ALVGWFGHEL STRFKMDNKL QLIPGVCGFR ISNPPILLVC SLHASLEIFK QATMKALRKK SVLLTGYLEY LIKHNYGKDK AATKKPVVNI ITPSHVEERG CQLTITFSVP NKDVFQELEK RGVVCDKRNP NGIRVAPVPL YNSFHDVYKF TNLLTSILDS AETKN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards