Ceramide glucosyltransferase (UGCG)

About Ceramide glucosyltransferase

Ceramide glucosyltransferase (UGCG) is a protein from Homo sapiens identified by UniProt accession Q16739, 394 residues long. MolForge cross-references it against 0 known binders and 239 disease associations.

Target properties

Protein name	Ceramide glucosyltransferase
UniProt accession	Q16739
Gene	UGCG
Organism	Homo sapiens
Length	394 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (3)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (239)

Diseases linked to this target (Open Targets).

Gaucher disease · score 0.58
Niemann-Pick disease type C · score 0.44
Red cell distribution width · score 0.44
mean corpuscular volume · score 0.39
erythrocyte count · score 0.38
Fabry disease · score 0.38
neurodegenerative disease · score 0.37
neutrophil count · score 0.36
Gaucher disease type 1 · score 0.34
Gaucher disease type 3 · score 0.33

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16739-F1	alphafold	PREDICTED	93.19	—

Amino-acid sequence (394 residues)

MALLDLALEG MAVFGFVLFL VLWLMHFMAI IYTRLHLNKK ATDKQPYSKL PGVSLLKPLK GVDPNLINNL ETFFELDYPK YEVLLCVQDH DDPAIDVCKK LLGKYPNVDA RLFIGGKKVG INPKINNLMP GYEVAKYDLI WICDSGIRVI PDTLTDMVNQ MTEKVGLVHG LPYVADRQGF AATLEQVYFG TSHPRYYISA NVTGFKCVTG MSCLMRKDVL DQAGGLIAFA QYIAEDYFMA KAIADRGWRF AMSTQVAMQN SGSYSISQFQ SRMIRWTKLR INMLPATIIC EPISECFVAS LIIGWAAHHV FRWDIMVFFM CHCLAWFIFD YIQLRGVQGG TLCFSKLDYA VAWFIRESMT IYIFLSALWD PTISWRTGRY RLRCGGTAEE ILDV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards