About Ubiquitin-conjugating enzyme E2 S
Ubiquitin-conjugating enzyme E2 S (UBE2S) is a protein
from Homo sapiens identified by UniProt accession
Q16763, 222 residues long.
MolForge cross-references it against 0 known binders and
75 disease associations.
Target properties
| Protein name | Ubiquitin-conjugating enzyme E2 S |
|---|
| UniProt accession | Q16763 |
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| Gene | UBE2S |
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| Organism | Homo sapiens |
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| Length | 222 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (75)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- vertebral joint disease · score 0.11
- hepatocellular carcinoma · score 0.11
- neoplasm · score 0.10
- cancer · score 0.08
- breast cancer · score 0.08
- Female infertility due to fertilization defect · score 0.06
- male infertility with teratozoospermia due to single gene mutation · score 0.05
- primary ovarian insufficiency · score 0.05
- female infertility due to oocyte meiotic arrest · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16763-F1 | alphafold | PREDICTED | 80.68 | — |
Amino-acid sequence (222 residues)
MNSNVENLPP HIIRLVYKEV TTLTADPPDG IKVFPNEEDL TDLQVTIEGP EGTPYAGGLF RMKLLLGKDF PASPPKGYFL TKIFHPNVGA NGEICVNVLK RDWTAELGIR HVLLTIKCLL IHPNPESALN EEAGRLLLEN YEEYAARARL LTEIHGGAGG PSGRAEAGRA LASGTEASST DPGAPGGPGG AEGPMAKKHA GERDKKLAAK KKTDKKRALR RL
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