Kynurenine--oxoglutarate transaminase 1 (KYAT1)

About Kynurenine--oxoglutarate transaminase 1

Kynurenine--oxoglutarate transaminase 1 (KYAT1) is a protein from Homo sapiens identified by UniProt accession Q16773, 422 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Kynurenine--oxoglutarate transaminase 1
UniProt accession	Q16773
Gene	KYAT1
Organism	Homo sapiens
Length	422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.18
high density lipoprotein cholesterol measurement · score 0.06
serum albumin measurement · score 0.06
allergic disease · score 0.06
attention deficit hyperactivity disorder · score 0.06
Neurofibromatosis type 6 · score 0.05
blood metabolite measurement · score 0.05
Tourette syndrome · score 0.05
attention deficit-hyperactivity disorder 8 · score 0.05
schizophrenia 15 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16773-F1	alphafold	PREDICTED	97.86	—

Amino-acid sequence (422 residues)

MAKQLQARRL DGIDYNPWVE FVKLASEHDV VNLGQGFPDF PPPDFAVEAF QHAVSGDFML NQYTKTFGYP PLTKILASFF GELLGQEIDP LRNVLVTVGG YGALFTAFQA LVDEGDEVII IEPFFDCYEP MTMMAGGRPV FVSLKPGPIQ NGELGSSSNW QLDPMELAGK FTSRTKALVL NTPNNPLGKV FSREELELVA SLCQQHDVVC ITDEVYQWMV YDGHQHISIA SLPGMWERTL TIGSAGKTFS ATGWKVGWVL GPDHIMKHLR TVHQNSVFHC PTQSQAAVAE SFEREQLLFR QPSSYFVQFP QAMQRCRDHM IRSLQSVGLK PIIPQGSYFL ITDISDFKRK MPDLPGAVDE PYDRRFVKWM IKNKGLVAIP VSIFYSVPHQ KHFDHYIRFC FVKDEATLQA MDEKLRKWKV EL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards