Guanylate kinase (GUK1)

About Guanylate kinase

Guanylate kinase (GUK1) is a protein from Homo sapiens identified by UniProt accession Q16774, 197 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Guanylate kinase
UniProt accession	Q16774
Gene	GUK1
Organism	Homo sapiens
Length	197 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
cutaneous melanoma · score 0.13
PHF-tau measurement · score 0.12
neurofibrillary tangles measurement · score 0.12
lung adenocarcinoma · score 0.10
cardiovascular disease · score 0.04
adenoma · score 0.03
hypertension · score 0.02
ovarian carcinoma · score 0.02
Sepsis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16774-F1	alphafold	PREDICTED	93.96	—

Amino-acid sequence (197 residues)

MSGPRPVVLS GPSGAGKSTL LKRLLQEHSG IFGFSVSHTT RNPRPGEENG KDYYFVTREV MQRDIAAGDF IEHAEFSGNL YGTSKVAVQA VQAMNRICVL DVDLQGVRNI KATDLRPIYI SVQPPSLHVL EQRLRQRNTE TEESLVKRLA AAQADMESSK EPGLFDVVII NDSLDQAYAE LKEALSEEIK KAQRTGA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards