Hydroxyacylglutathione hydrolase, mitochondrial (HAGH)

About Hydroxyacylglutathione hydrolase, mitochondrial

Hydroxyacylglutathione hydrolase, mitochondrial (HAGH) is a protein from Homo sapiens identified by UniProt accession Q16775, 308 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.

Target properties

Protein name	Hydroxyacylglutathione hydrolase, mitochondrial
UniProt accession	Q16775
Gene	HAGH
Organism	Homo sapiens
Length	308 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (102)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.38
Alzheimer disease · score 0.31
multiple sclerosis · score 0.31
lysosomal storage disease · score 0.31
Parkinson disease · score 0.31
insulin like growth factor measurement · score 0.19
mean corpuscular hemoglobin concentration · score 0.16
IGF-1 measurement · score 0.16
body height · score 0.14
mean corpuscular volume · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16775-F1	alphafold	PREDICTED	90.92	—

Amino-acid sequence (308 residues)

MVVGRGLLGR RSLAALGAAC ARRGLGPALL GVFCHTDLRK NLTVDEGTMK VEVLPALTDN YMYLVIDDET KEAAIVDPVQ PQKVVDAARK HGVKLTTVLT THHHWDHAGG NEKLVKLESG LKVYGGDDRI GALTHKITHL STLQVGSLNV KCLATPCHTS GHICYFVSKP GGSEPPAVFT GDTLFVAGCG KFYEGTADEM CKALLEVLGR LPPDTRVYCG HEYTINNLKF ARHVEPGNAA IREKLAWAKE KYSIGEPTVP STLAEEFTYN PFMRVREKTV QQHAGETDPV TTMRAVRREK DQFKMPRD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards