Histone H2B type 2-E (H2BC21)

About Histone H2B type 2-E

Histone H2B type 2-E (H2BC21) is a protein from Homo sapiens identified by UniProt accession Q16778, 126 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Histone H2B type 2-E
UniProt accession	Q16778
Gene	H2BC21
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

viral disease · score 0.50
infectious disease · score 0.50
cancer · score 0.39
melanoma · score 0.38
breast carcinoma · score 0.37
infection · score 0.08
infect · score 0.08
experimental autoimmune encephalomyelitis · score 0.07
triglyceride measurement · score 0.06
neoplasm · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16778-F1	alphafold	PREDICTED	88.30	—

Amino-acid sequence (126 residues)

MPEPAKSAPA PKKGSKKAVT KAQKKDGKKR KRSRKESYSI YVYKVLKQVH PDTGISSKAM GIMNSFVNDI FERIAGEASR LAHYNKRSTI TSREIQTAVR LLLPGELAKH AVSEGTKAVT KYTSSK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards