About NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (NDUFA9) is a protein
from Homo sapiens identified by UniProt accession
Q16795, 377 residues long.
MolForge cross-references it against 0 known binders and
250 disease associations.
Target properties
| Protein name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial |
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| UniProt accession | Q16795 |
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| Gene | NDUFA9 |
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| Organism | Homo sapiens |
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| Length | 377 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (250)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.61
- diabetes mellitus · score 0.60
- polycystic ovary syndrome · score 0.60
- type 1 diabetes mellitus · score 0.58
- gestational diabetes · score 0.58
- neurodegenerative disease · score 0.57
- obesity · score 0.57
- prediabetes syndrome · score 0.56
- mitochondrial complex I deficiency · score 0.56
- schizophrenia · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16795-F1 | alphafold | PREDICTED | 89.61 | — |
Amino-acid sequence (377 residues)
MAAAAQSRVV RVLSMSRSAI TAIATSVCHG PPCRQLHHAL MPHGKGGRSS VSGIVATVFG ATGFLGRYVV NHLGRMGSQV IIPYRCDKYD IMHLRPMGDL GQLLFLEWDA RDKDSIRRVV QHSNVVINLI GRDWETKNFD FEDVFVKIPQ AIAQLSKEAG VEKFIHVSHL NANIKSSSRY LRNKAVGEKV VRDAFPEAII VKPSDIFGRE DRFLNSFASM HRFGPIPLGS LGWKTVKQPV YVVDVSKGIV NAVKDPDANG KSFAFVGPSR YLLFHLVKYI FAVAHRLFLP FPLPLFAYRW VARVFEISPF EPWITRDKVE RMHITDMKLP HLPGLEDLGI QATPLELKAI EVLRRHRTYR WLSAEIEDVK PAKTVNI
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