About Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHKG1) is a protein
from Homo sapiens identified by UniProt accession
Q16816, 387 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform |
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| UniProt accession | Q16816 |
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| Gene | PHKG1 |
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| Organism | Homo sapiens |
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| Length | 387 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (50)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.37
- serine measurement · score 0.32
- amino acid measurement · score 0.27
- body height · score 0.27
- neurodegenerative disease · score 0.26
- bilirubin measurement · score 0.23
- serum alanine aminotransferase measurement · score 0.20
- glomerular filtration rate · score 0.19
- threonine measurement · score 0.17
- age at menopause · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16816-F1 | alphafold | PREDICTED | 87.07 | — |
Amino-acid sequence (387 residues)
MTRDEALPDS HSAQDFYENY EPKEILGRGV SSVVRRCIHK PTSQEYAVKV IDVTGGGSFS PEEVRELREA TLKEVDILRK VSGHPNIIQL KDTYETNTFF FLVFDLMKRG ELFDYLTEKV TLSEKETRKI MRALLEVICT LHKLNIVHRD LKPENILLDD NMNIKLTDFG FSCQLEPGER LREVCGTPSY LAPEIIECSM NEDHPGYGKE VDMWSTGVIM YTLLAGSPPF WHRKQMLMLR MIMSGNYQFG SPEWDDYSDT VKDLVSRFLV VQPQNRYTAE EALAHPFFQQ YLVEEVRHFS PRGKFKVIAL TVLASVRIYY QYRRVKPVTR EIVIRDPYAL RPLRRLIDAY AFRIYGHWVK KGQQQNRAAL FENTPKAVLL SLAEEDY
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