About Meprin A subunit alpha
Meprin A subunit alpha (MEP1A) is a protein
from Homo sapiens identified by UniProt accession
Q16819, 746 residues long.
MolForge cross-references it against 0 known binders and
50 disease associations.
Target properties
| Protein name | Meprin A subunit alpha |
|---|
| UniProt accession | Q16819 |
|---|
| Gene | MEP1A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 746 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (50)
Diseases linked to this target (Open Targets).
- Chlamydiaceae Infections · score 0.26
- blood protein measurement · score 0.10
- Barrett's esophagus · score 0.09
- hepatocellular carcinoma · score 0.06
- neoplasm · score 0.05
- esophageal adenocarcinoma · score 0.04
- interstitial cystitis · score 0.03
- hyper-IgE recurrent infection syndrome 5, autosomal recessive · score 0.03
- X-linked lymphoproliferative disease · score 0.03
- ulcerative colitis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16819-F1 | alphafold | PREDICTED | 84.55 | — |
Amino-acid sequence (746 residues)
MAWIRSTCIL FFTLLFAHIA AVPIKYLPEE NVHDADFGEQ KDISEINLAA GLDLFQGDIL LQKSRNGLRD PNTRWTFPIP YILADNLGLN AKGAILYAFE MFRLKSCVDF KPYEGESSYI IFQQFDGCWS EVGDQHVGQN ISIGQGCAYK AIIEHEILHA LGFYHEQSRT DRDDYVNIWW DQILSGYQHN FDTYDDSLIT DLNTPYDYES LMHYQPFSFN KNASVPTITA KIPEFNSIIG QRLDFSAIDL ERLNRMYNCT TTHTLLDHCT FEKANICGMI QGTRDDTDWA HQDSAQAGEV DHTLLGQCTG AGYFMQFSTS SGSAEEAALL ESRILYPKRK QQCLQFFYKM TGSPSDRLVV WVRRDDSTGN VRKLVKVQTF QGDDDHNWKI AHVVLKEEQK FRYLFQGTKG DPQNSTGGIY LDDITLTETP CPTGVWTVRN FSQVLENTSK GDKLQSPRFY NSEGYGFGVT LYPNSRESSG YLRLAFHVCS GENDAILEWP VENRQVIITI LDQEPDVRNR MSSSMVFTTS KSHTSPAIND TVIWDRPSRV GTYHTDCNCF RSIDLGWSGF ISHQMLKRRS FLKNDDLIIF VDFEDITHLS QTEVPTKGKR LSPQGLILQG QEQQVSEEGS GKAMLEEALP VSLSQGQPSR QKRSVENTGP LEDHNWPQYF RDPCDPNPCQ NDGICVNVKG MASCRCISGH AFFYTGERCQ AVQVHGSVLG MVIGGTAGVI FLTFSIIAIL SQRPRK
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