About Phosphoenolpyruvate carboxykinase [GTP], mitochondrial
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (PCK2) is a protein
from Homo sapiens identified by UniProt accession
Q16822, 640 residues long.
MolForge cross-references it against 0 known binders and
194 disease associations.
Target properties
| Protein name | Phosphoenolpyruvate carboxykinase [GTP], mitochondrial |
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| UniProt accession | Q16822 |
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| Gene | PCK2 |
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| Organism | Homo sapiens |
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| Length | 640 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (194)
Diseases linked to this target (Open Targets).
- phosphoenolpyruvate carboxykinase deficiency, mitochondrial · score 0.51
- phosphoenolpyruvate carboxykinase deficiency · score 0.37
- Peripheral neuropathy · score 0.18
- Gait disturbance · score 0.18
- peripheral neuropathy · score 0.18
- triglyceride measurement · score 0.17
- smoking status measurement · score 0.15
- retinitis pigmentosa · score 0.15
- neoplasm · score 0.10
- hepatocellular carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16822-F1 | alphafold | PREDICTED | 93.92 | — |
Amino-acid sequence (640 residues)
MAALYRPGLR LNWHGLSPLG WPSCRSIQTL RVLSGDLGQL PTGIRDFVEH SARLCQPEGI HICDGTEAEN TATLTLLEQQ GLIRKLPKYN NCWLARTDPK DVARVESKTV IVTPSQRDTV PLPPGGARGQ LGNWMSPADF QRAVDERFPG CMQGRTMYVL PFSMGPVGSP LSRIGVQLTD SAYVVASMRI MTRLGTPVLQ ALGDGDFVKC LHSVGQPLTG QGEPVSQWPC NPEKTLIGHV PDQREIISFG SGYGGNSLLG KKCFALRIAS RLARDEGWLA EHMLILGITS PAGKKRYVAA AFPSACGKTN LAMMRPALPG WKVECVGDDI AWMRFDSEGR LRAINPENGF FGVAPGTSAT TNPNAMATIQ SNTIFTNVAE TSDGGVYWEG IDQPLPPGVT VTSWLGKPWK PGDKEPCAHP NSRFCAPARQ CPIMDPAWEA PEGVPIDAII FGGRRPKGVP LVYEAFNWRH GVFVGSAMRS ESTAAAEHKG KIIMHDPFAM RPFFGYNFGH YLEHWLSMEG RKGAQLPRIF HVNWFRRDEA GHFLWPGFGE NARVLDWICR RLEGEDSARE TPIGLVPKEG ALDLSGLRAI DTTQLFSLPK DFWEQEVRDI RSYLTEQVNQ DLPKEVLAEL EALERRVHKM
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