Dual specificity protein phosphatase 6 (DUSP6)

About Dual specificity protein phosphatase 6

Dual specificity protein phosphatase 6 (DUSP6) is a protein from Homo sapiens identified by UniProt accession Q16828, 381 residues long. MolForge cross-references it against 0 known binders and 287 disease associations.

Target properties

Protein name	Dual specificity protein phosphatase 6
UniProt accession	Q16828
Gene	DUSP6
Organism	Homo sapiens
Length	381 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (287)

Diseases linked to this target (Open Targets).

Kallmann syndrome · score 0.58
body mass index · score 0.44
body fat percentage · score 0.44
attention deficit hyperactivity disorder · score 0.43
lean body mass · score 0.41
mathematical ability · score 0.40
self reported educational attainment · score 0.39
aspartate aminotransferase measurement · score 0.38
fat body mass · score 0.38
hypogonadotropic hypogonadism · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16828-F1	alphafold	PREDICTED	75.24	—

Amino-acid sequence (381 residues)

MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESVLGLLLK KLKDEGCRAF YLEGGFSKFQ AEFSLHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ QLYFTTPSNQ NVYQVDSLQS T

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards