Dual specificity protein phosphatase 7 (DUSP7)

About Dual specificity protein phosphatase 7

Dual specificity protein phosphatase 7 (DUSP7) is a protein from Homo sapiens identified by UniProt accession Q16829, 419 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Dual specificity protein phosphatase 7
UniProt accession	Q16829
Gene	DUSP7
Organism	Homo sapiens
Length	419 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

neuroinflammatory disorder · score 0.36
thyroid gland adenocarcinoma · score 0.30
breast adenocarcinoma · score 0.29
endometrial cancer · score 0.21
neurodegenerative disease · score 0.19
cutaneous melanoma · score 0.18
lung adenocarcinoma · score 0.18
platelet component distribution width · score 0.14
macrophage inflammatory protein 1b measurement · score 0.13
platelet count · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16829-F1	alphafold	PREDICTED	74.03	—

Amino-acid sequence (419 residues)

MKNQLRGPPA RAHMSTSGAA AAGGTRAGSE PGAGSGSGAG TGAGAATGAG AMPCKSAEWL QEELEARGGA SLLLLDCRPH ELFESSHIET AINLAIPGLM LRRLRKGNLP IRSIIPNHAD KERFATRCKA ATVLLYDEAT AEWQPEPGAP ASVLGLLLQK LRDDGCQAYY LQGGFNKFQT EYSEHCETNV DSSSSPSSSP PTSVLGLGGL RISSDCSDGE SDRELPSSAT ESDGSPVPSS QPAFPVQILP YLYLGCAKDS TNLDVLGKYG IKYILNVTPN LPNAFEHGGE FTYKQIPISD HWSQNLSQFF PEAISFIDEA RSKKCGVLVH CLAGISRSVT VTVAYLMQKM NLSLNDAYDF VKRKKSNISP NFNFMGQLLD FERTLGLSSP CDNHASSEQL YFSTPTNHNL FPLNTLEST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards