About Uridine phosphorylase 1
Uridine phosphorylase 1 (UPP1) is a protein
from Homo sapiens identified by UniProt accession
Q16831, 310 residues long.
MolForge cross-references it against 0 known binders and
182 disease associations.
Target properties
| Protein name | Uridine phosphorylase 1 |
|---|
| UniProt accession | Q16831 |
|---|
| Gene | UPP1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 310 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (182)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- leukocyte count · score 0.36
- myeloid white cell count · score 0.34
- basophil percentage of leukocytes · score 0.25
- cutaneous melanoma · score 0.22
- neutrophil count · score 0.21
- mean reticulocyte volume · score 0.19
- neoplasm · score 0.11
- lung adenocarcinoma · score 0.09
- bladder transitional cell carcinoma · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16831-F1 | alphafold | PREDICTED | 94.28 | — |
Amino-acid sequence (310 residues)
MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF GDVKFVCVGG SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYKV GPVLSVSHGM GIPSISIMLH ELIKLLYYAR CSNVTIIRIG TSGGIGLEPG TVVITEQAVD TCFKAEFEQI VLGKRVIRKT DLNKKLVQEL LLCSAELSEF TTVVGNTMCT LDFYEGQGRL DGALCSYTEK DKQAYLEAAY AAGVRNIEME SSVFAAMCSA CGLQAAVVCV TLLNRLEGDQ ISSPRNVLSE YQQRPQRLVS YFIKKKLSKA
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