About Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) is a protein
from Homo sapiens identified by UniProt accession
Q16836, 314 residues long.
MolForge cross-references it against 0 known binders and
209 disease associations.
Target properties
| Protein name | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial |
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| UniProt accession | Q16836 |
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| Gene | HADH |
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| Organism | Homo sapiens |
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| Length | 314 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (209)
Diseases linked to this target (Open Targets).
- Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency · score 0.74
- 3-hydroxyacyl-CoA dehydrogenase deficiency · score 0.74
- hyperinsulinemic hypoglycemia, familial, 4 · score 0.68
- hyperinsulinemic hypoglycemia · score 0.41
- hair colour measurement · score 0.30
- Abnormal brain morphology · score 0.27
- ulcerative colitis · score 0.23
- genetic disorder · score 0.19
- monogenic diabetes · score 0.18
- Osteopenia · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16836-F1 | alphafold | PREDICTED | 96.82 | — |
Amino-acid sequence (314 residues)
MAFVTRQFMR SVSSSSTASA SAKKIIVKHV TVIGGGLMGA GIAQVAAATG HTVVLVDQTE DILAKSKKGI EESLRKVAKK KFAENLKAGD EFVEKTLSTI ATSTDAASVV HSTDLVVEAI VENLKVKNEL FKRLDKFAAE HTIFASNTSS LQITSIANAT TRQDRFAGLH FFNPVPVMKL VEVIKTPMTS QKTFESLVDF SKALGKHPVS CKDTPGFIVN RLLVPYLMEA IRLYERGDAS KEDIDTAMKL GAGYPMGPFE LLDYVGLDTT KFIVDGWHEM DAENPLHQPS PSLNKLVAEN KFGKKTGEGF YKYK
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