About UTP--glucose-1-phosphate uridylyltransferase
UTP--glucose-1-phosphate uridylyltransferase (UGP2) is a protein
from Homo sapiens identified by UniProt accession
Q16851, 508 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | UTP--glucose-1-phosphate uridylyltransferase |
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| UniProt accession | Q16851 |
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| Gene | UGP2 |
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| Organism | Homo sapiens |
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| Length | 508 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (76)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 83 · score 0.63
- neuroinflammatory disorder · score 0.26
- genetic disorder · score 0.19
- cutaneous melanoma · score 0.18
- squamous cell lung carcinoma · score 0.10
- hepatocellular carcinoma · score 0.10
- endometrial cancer · score 0.09
- neuroticism measurement · score 0.07
- diastolic blood pressure · score 0.06
- wellbeing measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16851-F1 | alphafold | PREDICTED | 88.54 | — |
Amino-acid sequence (508 residues)
MSRFVQDLSK AMSQDGASQF QEVIRQELEL SVKKELEKIL TTASSHEFEH TKKDLDGFRK LFHRFLQEKG PSVDWGKIQR PPEDSIQPYE KIKARGLPDN ISSVLNKLVV VKLNGGLGTS MGCKGPKSLI GVRNENTFLD LTVQQIEHLN KTYNTDVPLV LMNSFNTDED TKKILQKYNH CRVKIYTFNQ SRYPRINKES LLPVAKDVSY SGENTEAWYP PGHGDIYASF YNSGLLDTFI GEGKEYIFVS NIDNLGATVD LYILNHLMNP PNGKRCEFVM EVTNKTRADV KGGTLTQYEG KLRLVEIAQV PKAHVDEFKS VSKFKIFNTN NLWISLAAVK RLQEQNAIDM EIIVNAKTLD GGLNVIQLET AVGAAIKSFE NSLGINVPRS RFLPVKTTSD LLLVMSNLYS LNAGSLTMSE KREFPTVPLV KLGSSFTKVQ DYLRRFESIP DMLELDHLTV SGDVTFGKNV SLKGTVIIIA NHGDRIDIPP GAVLENKIVS GNLRILDH
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