Deoxyguanosine kinase, mitochondrial (DGUOK)

About Deoxyguanosine kinase, mitochondrial

Deoxyguanosine kinase, mitochondrial (DGUOK) is a protein from Homo sapiens identified by UniProt accession Q16854, 277 residues long. MolForge cross-references it against 0 known binders and 134 disease associations.

Target properties

Protein name	Deoxyguanosine kinase, mitochondrial
UniProt accession	Q16854
Gene	DGUOK
Organism	Homo sapiens
Length	277 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (134)

Diseases linked to this target (Open Targets).

mitochondrial DNA depletion syndrome 3 (hepatocerebral type) · score 0.80
progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 · score 0.77
Mitochondrial DNA depletion syndrome, hepatocerebral form due to DGUOK deficiency · score 0.75
portal hypertension · score 0.65
mitochondrial DNA depletion syndrome · score 0.55
genetic disorder · score 0.49
mitochondrial disease · score 0.37
Cholestasis · score 0.37
neurodegenerative disease · score 0.37
cholestasis · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16854-F1	alphafold	PREDICTED	86.08	—

Amino-acid sequence (277 residues)

MAAGRLFLSR LRAPFSSMAK SPLEGVSSSR GLHAGRGPRR LSIEGNIAVG KSTFVKLLTK TYPEWHVATE PVATWQNIQA AGTQKACTAQ SLGNLLDMMY REPARWSYTF QTFSFLSRLK VQLEPFPEKL LQARKPVQIF ERSVYSDRYI FAKNLFENGS LSDIEWHIYQ DWHSFLLWEF ASRITLHGFI YLQASPQVCL KRLYQRAREE EKGIELAYLE QLHGQHEAWL IHKTTKLHFE ALMNIPVLVL DVNDDFSEEV TKQEDLMREV NTFVKNL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards