V-type proton ATPase subunit F (ATP6V1F)

About V-type proton ATPase subunit F

V-type proton ATPase subunit F (ATP6V1F) is a protein from Homo sapiens identified by UniProt accession Q16864, 119 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	V-type proton ATPase subunit F
UniProt accession	Q16864
Gene	ATP6V1F
Organism	Homo sapiens
Length	119 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
dilated cardiomyopathy · score 0.10
hepatocellular carcinoma · score 0.05
electrocardiography · score 0.02
neoplasm · score 0.01
post-traumatic stress disorder · score 0.01
Miyoshi myopathy · score 0.01
Alzheimer disease · score 0.01
cancer · score 0.00
infect · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16864-F1	alphafold	PREDICTED	86.86	—

Amino-acid sequence (119 residues)

MAGRGKLIAV IGDEDTVTGF LLGGIGELNK NRHPNFLVVE KDTTINEIED TFRQFLNRDD IGIILINQYI AEMVRHALDA HQQSIPAVLE IPSKEHPYDA AKDSILRRAR GMFTAEDLR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards