About 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) is a protein
from Homo sapiens identified by UniProt accession
Q16875, 520 residues long.
MolForge cross-references it against 0 known binders and
333 disease associations.
Target properties
| Protein name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 |
|---|
| UniProt accession | Q16875 |
|---|
| Gene | PFKFB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 520 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (333)
Diseases linked to this target (Open Targets).
- hypothyroidism · score 0.33
- appendicular lean mass · score 0.30
- rheumatoid arthritis · score 0.30
- neuroinflammatory disorder · score 0.28
- thyroid disease · score 0.26
- myxedema · score 0.25
- celiac disease · score 0.24
- ulcerative colitis · score 0.24
- type 1 diabetes mellitus · score 0.24
- autoimmune disease · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16875-F1 | alphafold | PREDICTED | 86.61 | — |
Amino-acid sequence (520 residues)
MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY ISKKLTRYLN WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMKVRK QCALAALRDV KSYLAKEGGQ IAVFDATNTT RERRHMILHF AKENDFKAFF IESVCDDPTV VASNIMEVKI SSPDYKDCNS AEAMDDFMKR ISCYEASYQP LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM NIHVQPRTIY LCRHGENEHN LQGRIGGDSG LSSRGKKFAS ALSKFVEEQN LKDLRVWTSQ LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ DKYYYRYPTG ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL DKSAEEMPYL KCPLHTVLKL TPVAYGCRVE SIYLNVESVC THRERSEDAK KGPNPLMRRN SVTPLASPEP TKKPRINSFE EHVASTSAAL PSCLPPEVPT QLPGQNMKGS RSSADSSRKH
Explore 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets