About 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is a protein
from Homo sapiens identified by UniProt accession
Q16877, 469 residues long.
MolForge cross-references it against 0 known binders and
118 disease associations.
Target properties
| Protein name | 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 |
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| UniProt accession | Q16877 |
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| Gene | PFKFB4 |
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| Organism | Homo sapiens |
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| Length | 469 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (118)
Diseases linked to this target (Open Targets).
- health study participation · score 0.18
- endometrial cancer · score 0.12
- BMI-adjusted waist-hip ratio · score 0.11
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.10
- BMI-adjusted waist circumference · score 0.10
- melanoma · score 0.09
- breast cancer · score 0.09
- triple-negative breast cancer · score 0.09
- non-small cell lung carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16877-F1 | alphafold | PREDICTED | 92.41 | — |
Amino-acid sequence (469 residues)
MASPRELTQN PLKKIWMPYS NGRPALHACQ RGVCMTNCPT LIVMVGLPAR GKTYISKKLT RYLNWIGVPT REFNVGQYRR DVVKTYKSFE FFLPDNEEGL KIRKQCALAA LRDVRRFLSE EGGHVAVFDA TNTTRERRAT IFNFGEQNGY KTFFVESICV DPEVIAANIV QVKLGSPDYV NRDSDEATED FMRRIECYEN SYESLDEDLD RDLSYIKIMD VGQSYVVNRV ADHIQSRIVY YLMNIHVTPR SIYLCRHGES ELNLKGRIGG DPGLSPRGRE FAKSLAQFIS DQNIKDLKVW TSQMKRTIQT AEALGVPYEQ WKVLNEIDAG VCEEMTYEEI QDNYPLEFAL RDQDKYRYRY PKGESYEDLV QRLEPVIMEL ERQENVLVIC HQAVMRCLLA YFLDKAAEQL PYLKCPLHTV LKLTPVAYGC KVESIFLNVA AVNTHRDRPQ NVDISRPPEE ALVTVPAHQ
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