About 2-hydroxyacylsphingosine 1-beta-galactosyltransferase
2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8) is a protein
from Homo sapiens identified by UniProt accession
Q16880, 541 residues long.
MolForge cross-references it against 0 known binders and
260 disease associations.
Target properties
| Protein name | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase |
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| UniProt accession | Q16880 |
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| Gene | UGT8 |
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| Organism | Homo sapiens |
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| Length | 541 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (260)
Diseases linked to this target (Open Targets).
- hemoglobin measurement · score 0.43
- erythrocyte count · score 0.41
- hematocrit · score 0.38
- red blood cell density measurement · score 0.34
- calcium measurement · score 0.33
- glomerular filtration rate · score 0.32
- urolithiasis · score 0.32
- blood phosphate measurement · score 0.30
- ureterolithiasis · score 0.27
- nephrolithiasis · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16880-F1 | alphafold | PREDICTED | 89.83 | — |
Amino-acid sequence (541 residues)
MKSYTPYFIL LWSAVGIAKA AKIIIVPPIM FESHMYIFKT LASALHERGH HTVFLLSEGR DIAPSNHYSL QRYPGIFNST TSDAFLQSKM RNIFSGRLTA IELFDILDHY TKNCDLMVGN HALIQGLKKE KFDLLLVDPN DMCGFVIAHL LGVKYAVFST GLWYPAEVGA PAPLAYVPEF NSLLTDRMNL LQRMKNTGVY LISRLGVSFL VLPKYERIMQ KYNLLPEKSM YDLVHGSSLW MLCTDVALEF PRPTLPNVVY VGGILTKPAS PLPEDLQRWV NGANEHGFVL VSFGAGVKYL SEDIANKLAG ALGRLPQKVI WRFSGPKPKN LGNNTKLIEW LPQNDLLGHS KIKAFLSHGG LNSIFETIYH GVPVVGIPLF GDHYDTMTRV QAKGMGILLE WKTVTEKELY EALVKVINNP SYRQRAQKLS EIHKDQPGHP VNRTIYWIDY IIRHNGAHHL RAAVHQISFC QYFLLDIAFV LLLGAALLYF LLSWVTKFIY RKIKSLWSRN KHSTVNGHYH NGILNGKYKR NGHIKHEKKV K
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