About MICOS complex subunit MIC60
MICOS complex subunit MIC60 (IMMT) is a protein
from Homo sapiens identified by UniProt accession
Q16891, 758 residues long.
MolForge cross-references it against 0 known binders and
170 disease associations.
Target properties
| Protein name | MICOS complex subunit MIC60 |
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| UniProt accession | Q16891 |
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| Gene | IMMT |
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| Organism | Homo sapiens |
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| Length | 758 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (170)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- FEV/FVC ratio · score 0.22
- diastolic blood pressure · score 0.17
- systolic blood pressure · score 0.15
- mean platelet volume · score 0.14
- metabolite measurement · score 0.11
- breast cancer · score 0.09
- reticulocyte count · score 0.09
- neoplasm · score 0.09
- platelet count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q16891-F1 | alphafold | PREDICTED | 73.81 | — |
Amino-acid sequence (758 residues)
MLRACQLSGV TAAAQSCLCG KFVLRPLRPC RRYSTSGSSG LTTGKIAGAG LLFVGGGIGG TILYAKWDSH FRESVEKTIP YSDKLFEMVL GPAAYNVPLP KKSIQSGPLK ISSVSEVMKE SKQPASQLQK QKGDTPASAT APTEAAQIIS AAGDTLSVPA PAVQPEESLK TDHPEIGEGK PTPALSEEAS SSSIRERPPE EVAARLAQQE KQEQVKIESL AKSLEDALRQ TASVTLQAIA AQNAAVQAVN AHSNILKAAM DNSEIAGEKK SAQWRTVEGA LKERRKAVDE AADALLKAKE ELEKMKSVIE NAKKKEVAGA KPHITAAEGK LHNMIVDLDN VVKKVQAAQS EAKVVSQYHE LVVQARDDFK RELDSITPEV LPGWKGMSVS DLADKLSTDD LNSLIAHAHR RIDQLNRELA EQKATEKQHI TLALEKQKLE EKRAFDSAVA KALEHHRSEI QAEQDRKIEE VRDAMENEMR TQLRRQAAAH TDHLRDVLRV QEQELKSEFE QNLSEKLSEQ ELQFRRLSQE QVDNFTLDIN TAYARLRGIE QAVQSHAVAE EEARKAHQLW LSVEALKYSM KTSSAETPTI PLGSAVEAIK ANCSDNEFTQ ALTAAIPPES LTRGVYSEET LRARFYAVQK LARRVAMIDE TRNSLYQYFL SYLQSLLLFP PQQLKPPPEL CPEDINTFKL LSYASYCIEH GDLELAAKFV NQLKGESRRV AQDWLKEARM TLETKQIVEI LTAYASAVGI GTTQVQPE
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