About Interphotoreceptor matrix proteoglycan 1
Interphotoreceptor matrix proteoglycan 1 (IMPG1) is a protein
from Homo sapiens identified by UniProt accession
Q17R60, 797 residues long.
MolForge cross-references it against 0 known binders and
39 disease associations.
Target properties
| Protein name | Interphotoreceptor matrix proteoglycan 1 |
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| UniProt accession | Q17R60 |
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| Gene | IMPG1 |
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| Organism | Homo sapiens |
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| Length | 797 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (39)
Diseases linked to this target (Open Targets).
- adult-onset foveomacular vitelliform dystrophy · score 0.64
- benign concentric annular macular dystrophy · score 0.64
- retinitis pigmentosa · score 0.60
- Retinal dystrophy · score 0.41
- inherited retinal dystrophy · score 0.37
- isolated macular dystrophy · score 0.34
- vitelliform macular dystrophy 2 · score 0.34
- gut microbiome measurement · score 0.33
- bone density · score 0.33
- Macular dystrophy · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q17R60-F1 | alphafold | PREDICTED | 58.46 | — |
Amino-acid sequence (797 residues)
MYLETRRAIF VFWIFLQVQG TKDISINIYH SETKDIDNPP RNETTESTEK MYKMSTMRRI FDLAKHRTKR SAFFPTGVKV CPQESMKQIL DSLQAYYRLR VCQEAVWEAY RIFLDRIPDT GEYQDWVSIC QQETFCLFDI GKNFSNSQEH LDLLQQRIKQ RSFPDRKDEI SAEKTLGEPG ETIVISTDVA NVSLGPFPLT PDDTLLNEIL DNTLNDTKMP TTERETEFAV LEEQRVELSV SLVNQKFKAE LADSQSPYYQ ELAGKSQLQM QKIFKKLPGF KKIHVLGFRP KKEKDGSSST EMQLTAIFKR HSAEAKSPAS DLLSFDSNKI ESEEVYHGTM EEDKQPEIYL TATDLKRLIS KALEEEQSLD VGTIQFTDEI AGSLPAFGPD TQSELPTSFA VITEDATLSP ELPPVEPQLE TVDGAEHGLP DTSWSPPAMA STSLSEAPPF FMASSIFSLT DQGTTDTMAT DQTMLVPGLT IPTSDYSAIS QLALGISHPP ASSDDSRSSA GGEDMVRHLD EMDLSDTPAP SEVPELSEYV SVPDHFLEDT TPVSALQYIT TSSMTIAPKG RELVVFFSLR VANMAFSNDL FNKSSLEYRA LEQQFTQLLV PYLRSNLTGF KQLEILNFRN GSVIVNSKMK FAKSVPYNLT KAVHGVLEDF RSAAAQQLHL EIDSYSLNIE PADQADPCKF LACGEFAQCV KNERTEEAEC RCKPGYDSQG SLDGLEPGLC GPGTKECEVL QGKGAPCRLP DHSENQAYKT SVKKFQNQQN NKVISKRNSE LLTVEYEEFN HQDWEGN
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