About Rho GTPase-activating protein 44
Rho GTPase-activating protein 44 (ARHGAP44) is a protein
from Homo sapiens identified by UniProt accession
Q17R89, 818 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | Rho GTPase-activating protein 44 |
|---|
| UniProt accession | Q17R89 |
|---|
| Gene | ARHGAP44 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 818 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (55)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.17
- PR interval · score 0.15
- QRS duration · score 0.10
- FEV/FVC ratio · score 0.09
- hair shape measurement · score 0.07
- peak expiratory flow · score 0.06
- balding measurement · score 0.05
- brain measurement · score 0.05
- cortical surface area measurement · score 0.05
- cortical thickness · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q17R89-F1 | alphafold | PREDICTED | 65.14 | — |
Amino-acid sequence (818 residues)
MKKQFNRMRQ LANQTVGRAE KTEVLSEDLL QVEKRLELVK QVSHSTHKKL TACLQGQQGA EADKRSKKLP LTTLAQCLME GSAILGDDTL LGKMLKLCGE TEDKLAQELI HFELQVERDV IEPLFLLAEV EIPNIQKQRK HLAKLVLDMD SSRTRWQQTS KSSGLSSSLQ PAGAKADALR EEMEEAANRV EICRDQLSAD MYSFVAKEID YANYFQTLIE VQAEYHRKSL TLLQAVLPQI KAQQEAWVEK PSFGKPLEEH LTISGREIAF PIEACVTMLL ECGMQEEGLF RVAPSASKLK KLKAALDCCV VDVQEYSADP HAIAGALKSY LRELPEPLMT FELYDEWIQA SNVQEQDKKL QALWNACEKL PKANHNNIRY LIKFLSKLSE YQDVNKMTPS NMAIVLGPNL LWPQAEGNIT EMMTTVSLQI VGIIEPIIQH ADWFFPGEIE FNITGNYGSP VHVNHNANYS SMPSPDMDPA DRRQPEQARR PLSVATDNMM LEFYKKDGLR KIQSMGVRVM DTNWVARRGS SAGRKVSCAP PSMQPPAPPA ELAAPLPSPL PEQPLDSPAA PALSPSGLGL QPGPERTSTT KSKELSPGSA QKGSPGSSQG TACAGTQPGA QPGAQPGASP SPSQPPADQS PHTLRKVSKK LAPIPPKVPF GQPGAMADQS AGQPSPVSLS PTPPSTPSPY GLSYPQGYSL ASGQLSPAAA PPLASPSVFT STLSKSRPTP KPRQRPTLPP PQPPTVNLSA SSPQSTEAPM LDGMSPGESM STDLVHFDIP SIHIELGSTL RLSPLEHMRR HSVTDKRDSE EESESTAL
Explore Rho GTPase-activating protein 44 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets