About Zinc finger protein 827
Zinc finger protein 827 (ZNF827) is a protein
from Homo sapiens identified by UniProt accession
Q17R98, 1081 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Zinc finger protein 827 |
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| UniProt accession | Q17R98 |
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| Gene | ZNF827 |
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| Organism | Homo sapiens |
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| Length | 1081 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- serum gamma-glutamyl transferase measurement · score 0.50
- serum alanine aminotransferase measurement · score 0.50
- aspartate aminotransferase measurement · score 0.50
- urate measurement · score 0.49
- heel bone mineral density · score 0.49
- alkaline phosphatase measurement · score 0.47
- pulse pressure measurement · score 0.46
- body height · score 0.45
- systolic blood pressure · score 0.43
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q17R98-F1 | alphafold | PREDICTED | 48.59 | — |
Amino-acid sequence (1081 residues)
MPRRKQEQPK RLPSHVSRQE EAEGELSEGE HWYGNSSETP SEASYGEVQE NYKLSLEDRI QEQSTSPDTS LGSTTPSSHT LELVALDSEV LRDSLQCQDH LSPGVSSLCD DDPGSNKPLS SNLRRLLEAG SLKLDAAATA NGRVESPVNV GSNLSFSPPS HHAQQLSVLA RKLAEKQEQN DQYTPSNRFI WNQGKWLPNS TTTCSLSPDS AILKLKAAAN AVLQDKSLTR TEETMRFESF SSPFSSQSAS STLAALSKKV SERSLTPGQE HPPPASSFLS LASMTSSAAL LKEVAARAAG SLLAEKSSLL PEDPLPPPPS EKKPEKVTPP PPPPPPPPPP PPPQSLELLL LPVPKGRVSK PSNSASEEES GKPFQCPICG LVIKRKSYWK RHMVIHTGLK SHQCPLCPFR CARKDNLKSH MKVHQHQDRG ETFQCQLCPF TSSRHFSLKL HMRCHQHFLR TEAKVKEEIP DPDVKGSPHL SDSACLGQQR EGGGTELVGT MMTSNTPERT SQGGAGVSPL LVKEEPKEDN GLPTSFTLNA ADRPANHTKL KDPSEYVANS ASALFSQDIS VKMASDFLMK LSAANQKEPM NLNFKVKEEP KEGESLSTTL PRSSYVFSPE SEVSAPGVSE DALKPQEGKG SVLRRDVSVK AASELLMKLS AESYKETQMV KIKEEPMEVD IQDSHVSISP SRNVGYSTLI GREKTEPLQK MPEGRVPPER NLFSQDISVK MASELLFQLS EKVSKEHNHT KENTIRTTTS PFFSEDTFRQ SPFTSNSKEL LPSDSVLHGR ISAPETEKIV LEAGNGLPSW KFNDQLFPCD VCGKVFGRQQ TLSRHLSLHT EERKYKCHLC PYAAKCRANL NQHLTVHSVK LVSTDTEDIV SAVTSEGSDG KKHPYYYSCH VCGFETELNV QFVSHMSLHV DKEQWMFSIC CTACDFVTME EAEIKTHIGT KHTGEDRKTP SESNSPSSSS LSALSDSANS KDDSDGSQKN KGGNNLLVIS VMPGSQPSLN SEEKPEKGFE CVFCNFVCKT KNMFERHLQI HLITRMFECD VCHKFMKTPE QLLEHKKCHT VPTGGLNSGQ W
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