About LON peptidase N-terminal domain and RING finger protein 1
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) is a protein
from Homo sapiens identified by UniProt accession
Q17RB8, 773 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | LON peptidase N-terminal domain and RING finger protein 1 |
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| UniProt accession | Q17RB8 |
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| Gene | LONRF1 |
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| Organism | Homo sapiens |
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| Length | 773 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (35)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.41
- high density lipoprotein cholesterol measurement · score 0.40
- type 2 diabetes mellitus · score 0.36
- self reported educational attainment · score 0.36
- BMI-adjusted waist-hip ratio · score 0.35
- body height · score 0.34
- mathematical ability · score 0.34
- apolipoprotein A 1 measurement · score 0.32
- neuroticism measurement · score 0.30
- wellbeing measurement · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q17RB8-F1 | alphafold | PREDICTED | 72.34 | — |
Amino-acid sequence (773 residues)
MSSPAVARTS PGGSREMAPA PQGRGRFWEV GGGSGHRLER AAAESERWEL LLRRGELLAL GGHLKGALEA FAAALRRGAP ARPECLGALV DCLVFNYRLR HGLGWSAAPV AGADGGAGGL LRCLGCRGFL SEPVTVPCGH SYCRRCLRRE LRARCRLCRD RLPPATASAT DAEGTAPRPP PLAAAIAASD FRTSVVLNHL AEKWFPGQRE RARAAGRLGE LLHQGRYREA LAAACEALRA EPSDLIVKIY RAESYAGLQE FKAAIEDLNA VLFQLPDWPE VYFRKGKVLC DAGFLGDALQ LFLQCLALDE DFAPAKLQVQ KILCDLLLPE NLKEGLKESS WSSLPCTKNR PFDFHSVMEE SQSLNEPSPK QSEEIPEVTS EPVKGSLNRA QSAQSINSTE MPAREDCLKR VSSEPVLSVQ EKGVLLKRKL SLLEQDVIVN EDGRNKLKKQ GETPNEVCMF SLAYGDIPEE LIDVSDFECS LCMRLFFEPV TTPCGHSFCK NCLERCLDHA PYCPLCKESL KEYLADRRYC VTQLLEELIV KYLPDELSER KKIYDEETAE LSHLTKNVPI FVCTMAYPTV PCPLHVFEPR YRLMIRRSIQ TGTKQFGMCV SDTQNSFADY GCMLQIRNVH FLPDGRSVVD TVGGKRFRVL KRGMKDGYCT ADIEYLEDVK VENEDEIKNL RELHDLVYSQ ACSWFQNLRD RFRSQILQHF GSMPEREENL QAAPNGPAWC WWLLAVLPVD PRYQLSVLSM KSLKERLTKI QHILTYFSRD QSK
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