About Exocyst complex component 3-like protein 4
Exocyst complex component 3-like protein 4 (EXOC3L4) is a protein
from Homo sapiens identified by UniProt accession
Q17RC7, 722 residues long.
MolForge cross-references it against 0 known binders and
24 disease associations.
Target properties
| Protein name | Exocyst complex component 3-like protein 4 |
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| UniProt accession | Q17RC7 |
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| Gene | EXOC3L4 |
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| Organism | Homo sapiens |
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| Length | 722 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (24)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.70
- serum gamma-glutamyl transferase measurement · score 0.68
- platelet count · score 0.58
- alkaline phosphatase measurement · score 0.44
- platelet component distribution width · score 0.42
- platelet crit · score 0.38
- primary biliary cirrhosis · score 0.37
- neurodegenerative disease · score 0.35
- non-alcoholic fatty liver disease · score 0.27
- mean corpuscular hemoglobin · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q17RC7-F1 | alphafold | PREDICTED | 78.12 | — |
Amino-acid sequence (722 residues)
MPSPQTDTPG PELQSPKEAE EPQTPAQGSR RTSSRKEPNA HRKDGTRLGL GSLRQAFSRA SQRALTQVSK EDTGLFRRSS CSLFRSFRQA LNDGPATGHS QATPEVPSGV MNGVSQQAST GAASEELKPE AEGKSVADLI TERQLLAAFE QLLRLETLLV AEKASRTFEQ DPTAFARRAM DVCLLYDGLA AEIGAIVRET LDSDGVDAAA LAELARVVSA EEEAHPSPPD DGDFLRTPRR WRQHWEEAVR RSAQERVRRP GAGWAFGEAE GASGLAQLLA ELGGLVRRDL QKVRQEVQPA YAAAGFPAWE VYLRAFHSAV AQRLQELARD ARGCEQLYIL LDWAANVYGS PDFLGAPGLA LPAEPLPPLL APDVWARLES DYTSFLEAKI ASCFDSILQL EQSHWAAAEV PEVLQGLYQA PLSMDVHMLV AEHVKAAGAI SAELEATTLR ICTRALGLFV PRFEKAFLAS EAVSEPHLGA YINACEELRT SLLSRFPGTQ EELEKPLVTA TCSFQKHLLQ GLQRELQPLF RVVCTRDWLT QDWLHPLMDK VVTFAGHLQR VARPRAQETL QEVHRFVVRE YLARALRPRE RFRGMERMHG SQKMSLDAQA ISDTFQGLGS EATWLDQAIQ CVAEILGETY KDDIQRHLET LIRSYPDIRR DHILAILALR RLGRQRNQHL LQHTQDLLRA AAGAAGAEAP RGRVLFEEIK VPSAMAVLIT CV
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