BTB/POZ domain-containing protein KCTD19 (KCTD19)

About BTB/POZ domain-containing protein KCTD19

BTB/POZ domain-containing protein KCTD19 (KCTD19) is a protein from Homo sapiens identified by UniProt accession Q17RG1, 926 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.

Target properties

Protein name	BTB/POZ domain-containing protein KCTD19
UniProt accession	Q17RG1
Gene	KCTD19
Organism	Homo sapiens
Length	926 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (174)

Diseases linked to this target (Open Targets).

Rare genetic intellectual disability with developmental anomaly · score 0.27
body height · score 0.16
mean corpuscular hemoglobin concentration · score 0.15
azoospermia · score 0.10
BMI-adjusted waist circumference · score 0.09
BMI-adjusted waist-hip ratio · score 0.09
Male infertility with spermatogenesis disorder due to single gene mutation · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.09
partial chromosome Y deletion · score 0.09
spermatogenic failure 61 · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q17RG1-F1	alphafold	PREDICTED	65.66	—

Amino-acid sequence (926 residues)

MEESGMAHES AEDLFHFNVG GWHFSVPRSK LSQFPDSLLW KEASALTSSE SQRLFIDRDG STFRHVHYYL YTSKLSFSSC AELNLLYEQA LGLQLMPLLQ TLDNLKEGKH HLRVRPADLP VAERASLNYW RTWKCISKPS EFPIKSPAFT GLHDKAPLGL MDTPLLDTEE EVHYCFLPLD LVAKYPSLVT EDNLLWLAET VALIECECSE FRFIVNFLRS QKILLPDNFS NIDVLEAEVE ILEIPALTEA VRWYRMNMGG CSPTTCSPLS PGKGARTASL ESVKPLYTMA LGLLVKYPDS ALGQLRIEST LDGSRLYITG NGVLFQHVKN WLGTCRLPLT ETISEVYELC AFLDKRDITY EPIKVALKTH LEPRTLAPMD VLNEWTAEIT VYSPQQIIKV YVGSHWYATT LQTLLKYPEL LSNPQRVYWI TYGQTLLIHG DGQMFRHILN FLRLGKLFLP SEFKEWPLFC QEVEEYHIPS LSEALAQCEA YKSWTQEKES ENEEAFSIRR LHVVTEGPGS LVEFSRDTKE TTAYMPVDFE DCSDRTPWNK AKGNLVRSNQ MDEAEQYTRP IQVSLCRNAK RAGNPSTYSH CRGLCTNPGH WGSHPESPPK KKCTTINLTQ KSETKDPPAT PMQKLISLVR EWDMVNCKQW EFQPLTATRS SPLEEATLQL PLGSEAASQP STSAAWKAHS TASEKDPGPQ AGAGAGAKDK GPEPTFKPYL PPKRAGTLKD WSKQRTKERE SPAPEQPLPE ASEVDSLGVI LKVTHPPVVG SDGFCMFFED SIIYTTEMDN LRHTTPTASP QPQEVTFLSF SLSWEEMFYA QKCHCFLADI IMDSIRQKDP KAITAKVVSL ANRLWTLHIS PKQFVVDLLA ITGFKDDRHT QERLYSWVEL TLPFARKYGR CMDLLIQRGL SRSVSYSILG KYLQED

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards