About Coiled-coil domain-containing protein 142
Coiled-coil domain-containing protein 142 (CCDC142) is a protein
from Homo sapiens identified by UniProt accession
Q17RM4, 750 residues long.
MolForge cross-references it against 0 known binders and
8 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 142 |
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| UniProt accession | Q17RM4 |
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| Gene | CCDC142 |
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| Organism | Homo sapiens |
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| Length | 750 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (8)
Diseases linked to this target (Open Targets).
- platelet count · score 0.22
- platelet crit · score 0.18
- serum urea measurement · score 0.09
- body height · score 0.08
- IGF-1 measurement · score 0.08
- appendicular lean mass · score 0.04
- Stress urinary incontinence · score 0.04
- systemic juvenile idiopathic arthritis · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q17RM4-F1 | alphafold | PREDICTED | 69.38 | — |
Amino-acid sequence (750 residues)
MAQASRSGSL PPLVIVPPLR AQPGGTGEEQ WERSRTGGLR WEVHCWPSGT SGGTPWWPTP ADVSEDYEAD AAAWRRGPAG GGPIPPALQR LRAVLLRLHR EREQLLQARD CAYHLQSAVR LMKTLSPGSP SGGPSPLPQW CRDLQLHPSQ GAVLRIGPGE TLEPLLLARP IGLAAQCLEA VIEMQLRALG REPASPGLSS QLAELLFALP AYHTLQRKAL SHVPGAARPF PTSRVLRLLT GERGCQVASR LDEALQGSAL RDQLRRRCQE EGDLLPGLLG LVGGVAGSAS CGLGLGGAGA LWSQYWTLLW AACAQSLDLN LGPWRDPRAT AQQLSQALGQ ASLPQECEKE LASLCHRLLH QSLIWSWDQG FCQALGSALG GQSSLPTSSG TAELLQQLFP PLLDALREPR LRRIFCQPAD PAPVALGLCT LQTTLLWFLG RAQQYLAAWD PASFLLLIQK DLPPLLHEAE ALYSLASEES LALEVEQQLG LEIQKLTAQI QLLPEESLSV FSQECHKQAM QGFKLYMPRG RYWRLRLCPE PPSAPSEYAG LVVRTVLEPV LQGLQGLPPQ AQAPALGQAL TAIVGAWLDH ILTHGIRFSL QGALQLKQDF GVVRELLEEE QWSLSPDLRQ TLLMLSIFQQ LDGALLCLLQ QPLPKSQVHR RPPCCCACQE VQTTKLPSSC LNSLESLEPP LQPGTSPAQT GQLQSTLGGR GPSPEGYLVG NQQAWLALRQ HQRPRWHLPF FSCLGTSPES
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